P-gp and BCRP are expressed in some normal tissues, to serve as protective barriers (i.e., in brain, placenta, testes) or for detoxification (i.e., in liver, kidney intestine), and is expressed at high levels in numerous tumor types (Gottesman et al., 2002; Leonard et al., 2003; Lee et al., 2010). Here, PGP is linked to neoplasm.