On the other hand, periodontal tissue destruction via osteoclastic action results in the sequestration of bone specific matrix proteins, like telopeptides type I collagen (5), osteocalcin (6), osteonectin (7), osteopontin (8) and bone phosphoprotein (9) in the gingival crevicular fluid, all of which have been positively associated with the progression of periodontal disease (10,11). Here, SPP1 is linked to periodontal disorder.