BP inhibit turnover and repairing capacity of the bone after micro damages (9), reducing also the epithelial cells proliferation rate in vitro, via the reduction of farnesyl diphosphate synthetase, and exhibiting also antiangiogenetic properties by decreasing the production of vascular endothelial growth factor (VEGF) (10,11), thus determining important effects on both quality and quantity of bone vascularization, possibly altering the response to trauma and infections (12). This evidence concerns the gene VEGFA and infection.