CD63/β1-integrins, CD63/Timp1 and Timp1/β1-integrins interactions were detected in the tumorigenic 4C11- and 4C11+ cell lines, suggesting that CD63/β1-integrins/Timp1 form a tighter complex when compared to that in pre-malignant melanocytes (4C), which could result in more efficient activation of PI3-K signaling pathway and in melanoma development (Figure 8), indicating the relevance of supramolecular complex formation in tumor progression. This evidence concerns the gene TIMP1 and melanoma.