SLC25A5 and malignant colon neoplasm: Herein, we attempted to investigate the following: 1) whether the combination of ANT2 shRNA and hNIS radioiodine gene therapy can induce more effective cytotoxic effects and phenotypic modulation in a mouse colon cancer model in vitro and in vivo; and 2) whether combination therapy can enhance the antitumor immunity of CTLs and tumor growth inhibition effects.