In western Kenya, a falciparum malaria holoendemic region, the most common clinical manifestation of severe malaria is severe malarial anemia [SMA (Hb < 6.0 g/dL)], with any density parasitemia [5,6], with respiratory distress, hypoglycemia and CM reported only in rare cases [7-9]. This evidence concerns the gene GSTM1 and parasitic infectious disease.