More recently, Logozzi et al. have demonstrated a strong expression of Cav1 in exosomes secreted by human melanoma cells in vitro and in those obtained from plasma of SCID mice engrafted with melanoma tumours: on the contrary, it is undetectable in cellular extracts and in exosomes from normal human cells such as primary monocyte-derived macrophages [132]. This evidence concerns the gene CAV1 and melanoma.