According to the binary logistic regression analysis, TNF-α, IL-1α, KC, G-CSF, IL-6, IL-12p70, IP-10, and MIP-1α are indicative for presence of S. aureus bacteremia in mice, while TNF-α, IL-1α, and KC were also potential biomarkers for fatal outcome of this infection. The gene discussed is CALCA; the disease is bacterial infectious disease with sepsis.