However, the IRPs RNA-binding activity is also regulated by several other exogenous and endogenous factors, such as oxidative stress [32], nitric oxide signaling [33], protein phosphorylation [34], hypoxia/reoxygenation [35], viral infections [36], estrogens [37], TCDD exposure [38], as well as oxalomalic acid, an inhibitor of IRP1/c-aconitase [39]. Here, ACO1 is linked to viral infectious disease.