In fact, the cellular levels of TfR-1 and ferritin are influenced by the co-presence of dioxin and virus infection, resulting in a marked TfR-1 expression increase (of about 1.7-fold after 24 and 48 h of treatment at 100 pg/ml) at the plasma membrane and a concomitant reduction in ferritin content (by approximately 0.4-fold after 24 and 48 h of treatment at 100 pg/ml) compared to control cultures. The gene discussed is TFRC; the disease is viral infectious disease.