As clearly shown in the graphs in Fig. 2C by comparing between the effects of BHV-1 infection and TCDD exposure taken individually or in combination, the increase in IRP2 RNA-binding activity was exclusively induced by the dioxin, whereas the decreasing trend in IRP1 activity was induced by both BHV-1 and dioxin alone [36], [38]. The gene discussed is IREB2; the disease is infection.