In agreement, our previous work showed that CD4+ and CD8+ CD73 KO or WT T cells proliferated equally in response to antigen-independent T cell receptor activation in vitro, and there was no significant difference in in vivo proliferation or IFN-γ production between CD73 KO and WT antigen-specific T cells in a tumor model [20]. The gene discussed is CD4; the disease is neoplasm.