Given that CD73 is closely involved in multiple processes vital to successful transplantation such as vascular permeability [29], leukocyte adhesion [30], [31], ischemic preconditioning [14], [32] and immunosuppression [11]–[13], and is important in solid organ allograft rejection [11], [27], [28], we hypothesized that CD73 would play a critical role in the T cell-mediated development of acute GVHD. The gene discussed is NT5E; the disease is acute graft versus host disease.