CIP further increased IL-1α, IL-13 and TNF-α to significantly higher concentrations in CI-mice than in vehicle-treated mice (Figure 2E–G); but CIP did not further increase IL-1β, IL-9, IL-10, GM-CSF, eotaxin and MIP-1α/β in CI-mice (Figure 2H–N). This evidence concerns the gene IL1B and hereditary sensory and autonomic neuropathy.