Quantitative analysis of microarray data confirmed that these methyltransferases, which included Setd3, Setd5, Suv39h2, Smyd3, Prmt3, Prmt6, Nsd1, and Nsd2 were up-regulated in metastases compared to adenomas, carcinomas, or disseminated cells (Table S1). This evidence concerns the gene PRMT3 and adenoma.