Tanaka H et al. show that N-cadherin silencing reduces AKT phosphorylation, whereas N-cadherin overexpression increases AKT activity in prostate cancer cells [40]; Similarly, Wallerand H et al. show that N-cadherin expression is associated with Akt activation and high invasiveness in human bladder cancer cell lines [41]. The gene discussed is CDH2; the disease is Familial prostate cancer.