Certain clinical factors that are highly sensitive to EGFR-TKI, such as adenocarcinoma, being a non-smoker, the female gender and the Asian race [47], [49]–[50], have been reported to be associated with EGFR gene mutations Christos Chouaid et al. assessed two cost-effectiveness analyses based the GFPC 0505 study. This evidence concerns the gene EGFR and adenocarcinoma.