In summary, by profiling EGFR phosphorylation in wild-type and mutant lung cancer cells, we identified a relationship between EGFR mutations and the phosphorylation of EGFR-Thr654 and -Ser1046, which was associated with AURKA expression in lung cancer patients and may be elicited by AURKA. The gene discussed is EGFR; the disease is lung carcinoma.