MBP and systemic lupus erythematosus: To analyze in more detail an “average” situation concerning hydrolysis of X-OP21 and X-OP25 by SLE anti-MBP IgGs we have used sle-IgGmix; Figs 1C and 1D demonstrate efficient hydrolysis of these specific encephalytogenic OPs by sle-IgGmix.