EGFR and non-small cell lung carcinoma: Several phase III clinical trials have confirmed that the presence of EGFR-activating mutations is predictive of a favorable outcome with EGFR-TKIs (i.e., gefitinib and erlotinib), compared with doublet chemotherapy, as first-line therapy for NSCLC, and in both Asian and Caucasian advanced NSCLC patients [4]–[7].