Given that IL-22 promotes hepatocyte survival in a T cell-mediated murine hepatitis model [3] and IFN-λ also affects cell viability [17], it was appropriate to examine the influence of IL-10RB K47E on cell survival in response to IFN-λ and IL-22 when cell death was induced by treatment with 5-FU, a chemotherapeutic agent (Fig. 3). The gene discussed is IL10RB; the disease is hepatitis A virus infection.