PPIB and cancer: For example, cilengitide is a cyclo[Arg-Gly-Asp-D-Phe-(NMeVal)] (cRGD) compound that acts as an antimigratory agent that targets the α(v)β(3) and α(v)β(5) integrins, which govern not only endothelial but also cancer cell adhesion; affecting thus both endothelial (angiogenesis) and cancer cell migratory (metastasis) processes, this compound has been assayed in multiple clinical trials, including studies on aggressive types of cancers [31,32].