SNAIL induction in the DLD1 colorectal cancer cells and knock-down of WISP-2 by RNA interference in MCF7 breast cancer cells (Supplementary Figure S5) led to morphologic changes [18,19] that coincide with induction of EMT and resistance to elisidepsin (Figure 3); inactivation of WISP or induction of SNAIL led to a 3–4 fold decrease in elisidepsin sensitivity in both models (1.7 μM vs. 9.0 μM in DLD/DLD-Snail and 5.3 μM vs. 18 μM in MCF7/MCF7-Wisp). Here, CCN5 is linked to colorectal cancer.