There is much evidence showing the relationship of IGF-IR and its ligands with the development and progression of PCa (Baserga et al., 1997; Hellawell and Brewster, 2002; Hellawell et al., 2002), which has been summarized as follows: IGF-IR plays a important role in cellular transformation, it has a critical role in the protection of cells from apoptosis, and its activation or over-expression mediates many aspects of malignant phenotype-like metastatic potential (Ozkan, 2011). This evidence concerns the gene IGF1R and posterior cortical atrophy.