In addition, meta-analysis studies have shown that IGF-I is significantly associated with a high relative risk for developing PCa (Harman et al., 2000; Shaneyfelt et al., 2000) and that PCa patients had significantly higher circulating levels of IGF-I (Stattin et al., 2000; Shi et al., 2001). Here, IGF1 is linked to posterior cortical atrophy.