A differential expression profile of the IGF-I isoforms between normal and cancerous tissues has been also observed in other human cancers in vivo, such as in cervical (Koczorowska et al., 2011) and colorectal cancer (Kasprzak et al., 2012), and in osteosarcoma cells in vitro (Philippou et al., 2011). This evidence concerns the gene IGF1 and cancer.