In addition, FGFβ, one of the decisive markers of glial growth, and VEGF, the most important factor of tumor vascularization and nutrition, were significantly down-regulated by AN-152 treatment (F4,19=7.8, p<0.01, Tukey's post hoc test: p<0.01 vs. control (n=5) for FGFβ; F4,11=4.8, p<0.05, Tukey's post hoc test: p<0.05 vs. control (n=3) for VEGF). This evidence concerns the gene FGF2 and neoplasm.