The increase in E-cadherin expression, and β-catenin degradation (Fig. 4-5) may inhibit the so-called cadherin-switch, when the expression pattern from E-cadherin changes to N-cadherin, resulting in loss of adhesion and stimulation of invasion.[42, 43] Moreover, AN-152 decreased the transcription of three (α4, αV, β5) contact activator integrin domains (Table 1), which are frequently over-expressed in GBM tumors.[44]. This evidence concerns the gene CDH17 and glioblastoma.