The flexibility of T cells to acquire NK-like phenotype and functions has also been confirmed by a recent report showing that in the absence of the transcription factor B-cell lymphoma/leukemia 11B (Bcl11b), murine immature double negative (DN) thymocytes are “re-programmed” to express NK cell receptors, to produce IFN-γ and to efficiently lyse tumor cells in the absence of antigen-specific stimulus (Li et al., 2010). The gene discussed is IFNG; the disease is neoplasm.