NCR3 and neoplasm: In particular, the expression of NKp46 and NKp30 is remarkably reduced on circulating and freshly purified NK cells from HIV-1 infected patients with high levels of chronic viremia, and this is directly associated with the decreased ability of NK cells to lyze NCR-ligand-positive tumor cell lines (De Maria et al., 2003; Mavilio et al., 2003, 2005).