Another research has reported that 12 genes were expressed differently in initial HCC versus dysplastic nodules: five were overexpressed (TERT, glypican-3, gankyrin, survivin, TOP2A) and seven were subexpressed (LYVE1, E-cadherin, IGFBP3, PDGFRA, TGFA, cyclin D1, HGF) [19]. The gene discussed is IGFBP3; the disease is hepatocellular carcinoma.