The RF- subtype develops RA along different pathways that are more associated with the DRB1*0301 [78], DRB1*08, DRB1*11, SLC11A1 [79] and HLA-B27 [80] genes, the use of the oral contraceptive pill [81], and increased IL-1ss and IL-12p40 cytokines leading to a monocyte-based inflammatory cascade [82]. The gene discussed is SLC11A1; the disease is rheumatoid arthritis.