We have preliminary data in other experimental models, including non-metastatic human A375 melanoma and HT-29 colorectal cancer (xenografted into nu/nu nude mice) (tumor volumes >400 mm3) and metastatic Lewis lung carcinoma (10 days after i.v. inoculation into C57BL/6 mice, tail vein), where increased circulating levels of ACTH, corticosterone and NORA, associate with a decrease in hepatic GSH levels (in all cases as compared to non-tumor-bearing controls) (not shown). This evidence concerns the gene POMC and colorectal cancer.