The role of IL-6 in cancer metastases is complex and may involve a) autocrine and paracrine mechanisms of IL-6 activity; b) direct growth stimulatory activity through activation of several signaling mechanisms; c) attraction of circulating immune and cancer cells to specific organs (e.g.lungs, brain, or liver) where IL-6 can be overexpressed; d) stimulation of neoangiogenesis and vascular remodeling; and e) promotion of inflammatory reactions and immune scape, thus contributing to an immune microenvironment that is favorable to tumor progression (e.g. [10-13]). The gene discussed is IL6; the disease is neoplasm.