Fibrinoid necrosis with extraglomerular vasculitic changes, associated with positive pANCA/anti-MPO antibodies indicated pauci-immune ANCA disease whereas intense linear IgG staining of the GBM pointed out to an anti–GBM disease [5,19,20], irrespective of normal (though high-normal) serum anti-GBM antibodies level [42]. This evidence concerns the gene MPO and glioblastoma.