For instance, NURR1 has been identified as a target of the anti-neoplastic drug 6-mercaptopurine, and may contribute to its anti-neoplastic functions, while 1, 1-bis(3′-indolyl)-1-(p-chlorophenyl)methane (DIM-C-pPhCl), an activator of NURR1 has been shown to mediate apoptosis in bladder cancer cells[10,23]. This evidence concerns the gene NR4A2 and urinary bladder cancer.