We did not observe statistically significant association with the risk of developing breast cancer for the SNPs in APC, DKK4 and LRP6 as well as some of the SNPs in β-catenin (rs13072632), AXIN2 (rs4791171, rs11079571 and rs3923086) and SFRP3 (rs288326) in the overall study population. This evidence concerns the gene DKK4 and breast cancer.