PPARGC1A and mitochondrial disease: Our expression profile from ETS abnormal aged muscle fibers detected common transcripts and gene products with other expression profiles from diverse models of mitochondrial disease: AMPK [34], CD36 [35], [36], Prohibitin [35], QPRT [37], pgc-1α [38] and mitochondrial Creatine Kinase [35], a protein known to form para-crystalline inclusions visible by electron microscopy in mitochondrial myopathy patients[39], [40].