Interestingly, advances in genome analysis have shown that rs738409 C/G, a nonsynonymous coding (I148M) gene variant located in human patatin-like phospholipase domain containing 3 gene (PNPLA3, also known as adiponutrin), is critically involved in the genetic susceptibility of fatty liver in both NAFLD [6], [7] and AFLD [8]. This evidence concerns the gene PNPLA3 and fatty liver disease.