HNF4A and cancer: Surprisingly, in addition to genes associated with IR or type 2 diabetes, i.e. HNF4A [20], the integrative functional analysis of the shared pathways between NAFLD and AFLD showed a significant enrichment of biological processes associated with cancer and neoplastic transformation of other nonhepatic tissues, such as colorectal, prostate, pancreas, bladder, renal, endometrial, and thyroid cancer (Figure S3).