Surprisingly, in addition to genes associated with IR or type 2 diabetes, i.e. HNF4A [20], the integrative functional analysis of the shared pathways between NAFLD and AFLD showed a significant enrichment of biological processes associated with cancer and neoplastic transformation of other nonhepatic tissues, such as colorectal, prostate, pancreas, bladder, renal, endometrial, and thyroid cancer (Figure S3). The gene discussed is HNF4A; the disease is type 2 diabetes mellitus.