Conversely, STAT3, IRS1, NCOR2 (a transcriptional co-repressor of NR4A2/NURR1 that acts through histone deacetylases, HDACs), and EP300 (E1A-binding protein p300 that functions as HDAC regulating transcription via chromatin remodeling during cell proliferation and differentiation) were significant for NAFLD (Table 1), suggesting, as we recently reported, that epigenetic factors play a critical role in the disease progression, not only involving nuclear DNA [23], but mitochondrial DNA as well [24]. This evidence concerns the gene IRS1 and metabolic dysfunction-associated steatotic liver disease.