SIRT1 and metabolic dysfunction-associated steatotic liver disease: Figure 3 summarizes the disease pathways shared by AFLD and NAFLD, and those that are overrepresented specifically for each disease. Remarkably, apoptosis, IL6-mediated signaling, NF-κ-β and JAK-STAT pathways, metabolism of lipids and lipoproteins, and pathways in cancer were placed in the overlapping zone and were shared between the two data sets. Accordingly, interleukins (1A, 3, 4, 10, and 18), adiponectin, PPARs (α and γ), sirtuin 1, TNFα, STAT3, INSR, SERBP1 or PAI-1, ICAM1, among the others, were also shared between the two sets (Figure 3).