Further studies are needed to determine whether rs1614972 plays a functional role in alcohol dependence risk, or is associated with the trait because it is in LD with other functional SNPs in ADH1C. Moreover, because of strong LD between SNPs in ADH1C and the ADH1B gene located near ADH1C[17], it is possible that the association is due to the effect of variants in ADH1B. Here, ADH1B is linked to alcohol dependence.