Phenotyping a subset of 23 AcB/BcA strains for susceptibility to AOM-induced CRC initially showed that differential susceptibility of A and B6 mouse strains to CRC is regulated by a single locus designated Ccs3. In these studies, Ccs3 was mapped to a 14 Mb segment on the central portion of chromosome 3 [33]. Here, BLNK is linked to colorectal carcinoma.