TGFB1 and inflammatory bowel disease: Interestingly, several key components of TGFβ-mediated Th17 and Th1 immune response pathways have recently been identified as low-penetrance loci associated with IBD onset, which could implicate TGFβ signaling in both IBD-linked as well as sporadic CRCs ([15], [16], reviewed in [19], [20]).