KCNN4 and glioblastoma: From the pathophysiological perspective, up-regulation of KCa3.1 expression is a common feature of activated and proliferating cells like T-cells [5], endothelial cells [10], neointimal smooth muscle cells [11], [12], fibroblasts [13], [14], and some cancer types such as glioblastomas [15], [16], [17].