Notwithstanding, the potencies of caffeic acid, resveratrol, and flufenamic acid as KCa3.1-inhibitors were moderate, but still may further advocate caffeic acid and resveratrol -as natural food additive-, or caffeic acid containing vegetable oils, like extra-virgin olive oil and argan oil, and the classical NSAID flufenamic acid for e.g. adjuvant immune suppressive or cytostatic treatments or for topical applications for inflammatory skin diseases. The gene discussed is KCNN4; the disease is inflammatory skin disease.