As the most important family of proteins that regulate the balance of the ECM, MMPs are a homologous group of zinc- and calcium-dependent matrix proteases and are thought to play a pivotal role in the pathogenesis of several central nervous system disorders and in the atherogenesis of intracranial arteries [31]–[34], and research has shown that MMP-2/-9 are by far the most closely related to the pathogenesis of intracranial aneurysms [35]. This evidence concerns the gene MMP2 and Dilatation of the cerebral artery.