Existing IA and genetic disease research confirms that the high expression of SPARC is closely related to the occurrence of intracranial aneurysms: approximately 5% of IA patients have a variety of genetic diseases, such as Ehlers-Danlos syndrome type IV, Marfan syndrome, neurofibromatosis type I and autosomal dominant polycystic kidney disease (of ADPKD), and it has been demonstrated that ADPKD has a clear correlation with IA (including asymptomatic aneurysms) [42]. Here, SPARC is linked to neurofibromatosis type 1.