Besides, we have also provide evidence that VEGFR2/PAK1 inhibition with VEGFR2 inhibitor Axitinib, or anti-VEGFR2 blocking antibody, or PAK1 allosteric inhibitor IPA3 administration could significantly blunt anoikis resistance in Klotho-overexpressed hepatoma cells. This evidence concerns the gene KDR and hepatocellular carcinoma.