Caspase 3/7 activity assay revealed that increased anoikis by VEGFR2 inhibitor Axitinib or its blocking antibody was partially reversed by PAK1 activation with PAK1 T423E cotransfection in Klotho-overexpressed hepatoma cells (Figure 8B, 8E). The gene discussed is CASP3; the disease is hepatocellular carcinoma.