Our study also explored the relationship(s) between changes in AT and biomarkers of inflammation associated with clinical outcomes, including: CRP and IL-6, which have been associated with mortality in HIV infection;[36]–[39] TNF-α, which is produced, along with IL-6, in excess by lipodystrophic AT; [40], [41] the anti-inflammatory cytokine adiponectin, whose production is suppressed in the setting of VAT accumulation; [42] and leptin, whose secretion increases with AT volume [42]. This evidence concerns the gene LEP and HIV infectious disease.