The most useful mesothelial and epithelial markers proposed for the diagnosis of mesothelioma are calretinin (a vitamin D-dependent calcium-binding protein involved in calcium signalling), HBME-1, thrombomodulin, WT-1, mesothelin, and podoplanin as mesothelial markers and pCEA, Ber-Ep4, TTF-2, B72.3 as epithelial markers [22]. The gene discussed is PDPN; the disease is mesothelioma.