On the other hand, O'Seaghdha et al (2011) found association of rs4821480 with CKD in European-Americans [31], but did not find an association with any of the APOL1 SNPs reported by Genovese et al (2010) and Tzur et al (2010), suggesting that variation in APOL1 may not be the complete explanation [29], [30]. Here, APOL1 is linked to chronic kidney disease.