As an example, heparanase enzyme [1], an endo-ß-glucoronidase, is a multifunctional enzyme influencing key steps of development of numerous types of cancers such as gastric [2], non-small lung [3], esophageal [4], head and neck [5], breast [6] and pancreatic [7] cancers as examples. This evidence concerns the gene HPSE and cancer.