Plasma concentrations of these markers did not correlate with RECIST response; however, modest but significant correlations were observed between tumor burden at week 8 (SLD) and sMET level (Spearman R = 0.5441, P = 0.0049), and VEGF-A level (Spearman R = 0.6216, P = 0.0012), respectively (Figure 4). This evidence concerns the gene VEGFA and neoplasm.