ALB and Insulin resistance: The absence of insulin resistance in mice with homozygous or heterozygous Crif1 deletion in the liver (Crif1f/f,Alb, Albumin-Cre) or skeletal muscle (Crif1f/+,MLC, MLC-Cre) is in agreement with previous findings that hepatic and skeletal mitochondrial dysfunction does not cause insulin resistance (Figure S10).