The absence of insulin resistance in mice with homozygous or heterozygous Crif1 deletion in the liver (Crif1f/f,Alb, Albumin-Cre) or skeletal muscle (Crif1f/+,MLC, MLC-Cre) is in agreement with previous findings that hepatic and skeletal mitochondrial dysfunction does not cause insulin resistance (Figure S10). This evidence concerns the gene GADD45GIP1 and Insulin resistance.