BRAF and melanoma: Indeed, Shi et al. (2012b) demonstrated that 20% of melanoma patients treated with BRAF inhibitors (Vemurafenib and Dabrafenib) showed an increase in genomic copy number of BRAFV600E and BRAFV600E amplification resulted in BRAFV600E overexpression in tumors of melanoma patients whose cancer had progressed after initial response.