All NSCLC cell lines were highly sensitive (IC50 range 0.0006–0.14 μM) to panobinostat (HDACi), and almost all NSCLC cell lines were sensitive (IC50 range 0.29–1.2 μM) to belinostat (HDACi) except the EGFR-normal H1666 cell line (IC50 range >10 μM). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.