In addition, we also observed that there was a new set of PrP spots designated PrP 2D spots VII present in the two conditions including fCJDIns and non-CJD, migrating at ~26-27 kDa with pI 5.0-8.1 (Fig. 7C and 7D). The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.