For example, angiotensin-converting enzyme (ACE) inhibitors are very effective at lowering BP by inhibition of the renin–angiotensin–aldosterone system (RAAS); however, these agents are often associated with significant cough and more rarely with angioedema.10 To achieve better BP control and to improve patient adherence with the treatment, it is necessary to prescribe more potent, yet well-tolerated antihypertensive agents. The gene discussed is ACE; the disease is angioedema.