In cases of advanced MTC with ectopic corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) production leading to Cushing syndrome, the use of somatostatin analogues, especially when combined with interferon-alpha, improved diarrhea only transitorily in a few patients [12]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.