Second, although abdominal obesity can be easily assessed using the simple measure of WC, other complex measures such as the body fat distribution (by dual energy X-ray absorptiometry or magnetic resonance imaging), or adipose tissue biomarkers such as leptin and adiponectin, may be appropriate surrogate markers of central obesity and should play an important role in childhood MetS research [4]. This evidence concerns the gene LEP and Abdominal obesity.