When analyzed with regard to various clinicopathological parameters, such as gender (P = 0.804), age (P = 0.432), tumor differentiation (P =0.032), pT factor (P = 0.234), lymph node metastasis (P = 0.545), distant metastasis (P = 0.543) and TNM stage (P = 0.002; Table 1), multivariate Cox regression analysis revealed that WDR66 expression remained an independent prognostic factor (P = 0.042; Table 1). The gene discussed is CFAP251; the disease is neoplasm.