CD69 and neoplasm: CD4 + CD107a + and CD8 + CD69+ populations were increased in CRLM compared to populations in non-tumor liver tissue (7.4% ± 0.7 vs. 3.5% ± 0.8, p = 0.04 ; 50% ± 0.9 vs. 30.6% ± 0.5 p = 0.0003 , respectively) (Figure 2C).