In regard to the architectural location of the T-cells in the tumor microenvironment, the number of LIGHT-expressing CD3+ (6.33 ± 2.40 vs. 0.33 ± .33, p = .000056), CD4+ (5.33 ± 1.20 vs. 0.33 ± .33, p = .0009), and CD8+ (5.67 ± 2.40 vs. 1.67 ± 0.33, p = .029) lymphocytes were significantly higher in the peritumor region compared to the intratumor region (Figure 5). This evidence concerns the gene CD4 and neoplasm.